
Endocrine evaluation and treatment is very
complex and you must have an experienced physician. For bioidentical
hormones you should have a physician experienced in this particular area.
1. Thyroid: Hypothyroidism in the elderly is common and symptoms can be non-specific and affect many parts of the body. TSH, T4 and free T3 are common lab tests but may be normal with milder but symptomatic cases. The Barnes Axillary Temperature test predates modern lab testing and is easily done at home to screen for occult hypothyroidism. On awakening in the morning, without getting out of bed, place a thermometer in your axilla for five minutes. The normal is 97.8 to 98.2 degrees (not valid with fever, ovulation). For example, Dr. McNeel's wife Marilyn had a thyroidectomy in the 70's and had been taking Synthroid (T4) for 30 years. Her TSH and T4 tests had been normal for decades and she was tired all the time. Her initial Barnes test was 95 degrees. She changed to Armour thyroid (T4 & T3) and slowly increased with the Barnes test as a guide. Her test temperatures gradually increased to normal and she felt much better, was no longer tired and needing naps. Hyperthyroidism in the elderly is also a masquerader.
2. Estrogen: BioIdentical Hormones
refers to hormones that are identical to those in the human body, such as
estradiol
(the active form of estrogen),
progesterone,
testosterone and others. Opposed are the patented drugs such as
Premarin (pregnant
mare's urine, or horse estrogen) and
Provera, a
progestin or compound with progesterone properties. In this
complicated and controversial area it helps to understand the history and
politics, see
Dr. Erika's blog. The
BioIdentical Hormone Society trains physicians in this area.
Bioidentical estrogen is given as a cream or patch for skin absorption, which
avoids "first
pass" through the liver that occurs with pills and greatly reduces
risks of thromboembolism.
The oral route for estrogens
increases C Reactive Protein whereas the cutaneous route does not, possibly
reducing inflammation and cardiovascular risk. Estrogen replacement
therapy is associated with reduced
osteoporosis, reduced
colon cancer and possibly
increased
breast cancer.
Blood
and
24 hour urine female hormone test panels are available. For example, Dr. McNeel's wife Marilyn had been on Premarin for
30 years following a hysterectomy in the 70's. She changed to estrogen
cream (20% estradiol 80% estriol) from a
compounding pharmacy.
Her body initially rejected the estrogen and she had to take a ten week course
of cobalt (see J Wright; Ann NY Acad Sci 2005;1057:506-524) to reset her liver
enzymes. This worked, and she also takes small doses of testosterone
cream, oral
progesterone and
DHEA.
3.
Growth
hormone (GH) decreases markedly with age. GH stimulates the liver
to produce insulin like growth factor 1 (IGF1).
Decreasing GH and IGF1 with pituitary disease and/or age are associated with
decreased lean muscle mass, increased obesity especially abdominal, and
decreased bone density and osteoporosis. These findings can be reversed
to some extent by daily injections of growth hormone. The area is
controversial, however, as some physicians believe GH should only be given
to patients with
GH deficiency, and others use it as an anti-aging treatment. In
addition dosage is critical as with increasing dosages there are increasing side
effects, including joint pains, edema, carpal tunnel syndrome, and increased
insulin resistance and tendency to diabetes.
Urine test is available.
4.
Testosterone
also decreases with age, starting about age 40 in men with a gradual
decline. For most men this is not a major problem, but about 20% of men
over 60 will develop
hypogonadism
and
testosterone deficiency, which can result in reduced muscle mass and energy,
decreased libido, and decreased cognitive function. Testosterone therapy
can restore sexual function and muscle strength, prevent bone loss and protect
against heart disease. Risks include the theoretical possibility of
stimulating breast and prostate cancers in men, and prostate enlargement.
Blood
and
24 hour urine male hormone test panels are available. For
women, small doses of testosterone if deficient offer benefits of improved
sexual function and mood, but may cause facial hair and acne.
Cardiovascular risk may be reduced.
5.
Cortisol
is the "fight or flight" hormone from the adrenals in response to fear,
stress etc. In anti-aging medicine the two "hormones of death" are insulin
and cortisol; you must keep them down. Cortisol can save your life but if
chronically elevated is associated with shortening of telomeres and
premature death. Avoid chronic anger and hostility and other negative
emotions. Cortisol varies
during the day and testing can be done with
blood,
saliva
(cheaper) and
urine.
